منابع مشابه
LIN-12/Notch signaling in C. elegans.
Receptors of the LIN-12/Notch family mediate cell-cell interactions during animal development, and aberrations in LIN-12/Notch signaling have been implicated in human disease. Studies in C. elegans have been instrumental in defining the basic features of the LIN-12/Notch pathway, the role of LIN-12/Notch proteins as receptors for intercellular signals, the mechanism of signal transduction, and ...
متن کاملC. elegans LIN-18 Is a Ryk Ortholog and Functions in Parallel to LIN-17/Frizzled in Wnt Signaling
Wnt proteins are intercellular signals that regulate various aspects of animal development. In Caenorhabditis elegans, mutations in lin-17, a Frizzled-class Wnt receptor, and in lin-18 affect cell fate patterning in the P7.p vulval lineage. We found that lin-18 encodes a member of the Ryk/Derailed family of tyrosine kinase-related receptors, recently found to function as Wnt receptors. Members ...
متن کاملLeft-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway.
The C. elegans intestine is a simple tube consisting of a monolayer of epithelial cells. During embryogenesis, cells in the anterior of the intestinal primordium undergo reproducible movements that lead to an invariant, asymmetrical 'twist' in the intestine. We have analyzed the development of twist to determine how left-right and anterior-posterior asymmetries are generated within the intestin...
متن کاملLIN-44/Wnt Directs Dendrite Outgrowth through LIN-17/Frizzled in C. elegans Neurons
Nervous system function requires proper development of two functional and morphological domains of neurons, axons and dendrites. Although both these domains are equally important for signal transmission, our understanding of dendrite development remains relatively poor. Here, we show that in C. elegans the Wnt ligand, LIN-44, and its Frizzled receptor, LIN-17, regulate dendrite development of t...
متن کاملInvestigation of lin-4 independent regulation of lin-28 in the C. elegans heterochronic
developmental timing pathway. (1) SPECIFIC AIMS Appropriate temporal patterning is essential for embryogenesis and post-embryonic development. Progression through the four larval stages in C. elegans is regulated by 'heterochronic' genes (reviewed in Slack and Ruvkun 1997; Ambros 2000). Heterochronic genes encode a diverse set of proteins, mutations in which result in the reiteration or omissio...
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ژورنال
عنوان ژورنال: WormBook
سال: 2005
ISSN: 1551-8507
DOI: 10.1895/wormbook.1.10.1